News: Pregnenolone may play in a role in feedback loop that reduces CB receptor activation

http://www.ncbi.nlm.nih.gov/pubmed/24385629

Synthesis of pregnenolone, an inactive steroid precursor, is stimulated by THC-activated cannabinoid receptors (CB). Pregnenolone, in turn, can act as an inhibitor of CB receptors. This negative feedback mechanism may limit the degree of CB receptor excitation and cannabis intoxication. This finding could lead to novel treatments for cannabis use disorders.

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